Portfolio Leader (Cross Portfolio + Strategy & Operations)
- Location
- South San Francisco; Basel
- Work mode
- On-site
- Employment type
- Full-time
About the job
At Roche/Genentech, we have a bold Pharma Ambition to deliver 20 transformative medicines addressing diseases with the highest societal burden by 2030. With this vision top of mind, our purpose is to co-create and deliver the target portfolio for the benefit of patients. We want you to join our vision and be part of our passionate, collaborative, global PSM community!
We are a strong, close, trusting community that lives new ways of working and operates from a creative mindset. We are THE place for talent to grow and contribute; our talent feels valued, connected, and a sense of belonging to something impactful. We have high impact; customers draw on our expertise to help them deliver the target portfolio more effectively/efficiently. We stop lower-value work. We’re BOLD. We try things, openly discuss and learn from mistakes and failure, experiment and iterate to achieve our aspirations.
The Opportunity As Portfolio Leader, you will serve as a strategic partner and operational leader at the heart of our mission to actively shape and deliver a transformative Pharma portfolio. You will partner with the Head of PSM to drive the strategy, business planning, operations, and team culture, ensuring our PSM team is aligned, agile, and positioned for impact in a complex and evolving landscape.
Your responsibilities will also include leading and contributing to cross-portfolio initiatives, partnering with senior Pharma leaders and cross-functional teams to shape portfolio strategy, assess portfolio dynamics, and develop insights and strategic options to inform portfolio-wide decisions and prioritization. The balance between PSM-focused strategy and operations and broader portfolio-focused work may shift over time based on business needs. Accountabilities include, but are not limited to, the following areas:
- Strategic Partner: Partner with the Head of PSM and the PSM Leadership Team to realize the strategic vision for PSM, and translating vision into actionable priorities. Partner with fellow LT members to co-create and implement PSM-wide initiatives.
- PSM Ecosystem Architecture and Functioning: Serve as the primary architect and steward of the PSM ecosystem, ensuring that culture, communications, and operational frameworks are seamlessly integrated to drive collective success. Lead the planning and facilitation of PSM LT and All Staff meetings, leveraging agile practices to enable rigorous discussion, clear decision-making, and actionable outcomes. Oversee the holistic health of the PSM ecosystem by monitoring the intersection of team performance and organizational health, proactively identifying opportunities to strengthen the ecosystem.
- PSM Talent Deployment Architect and Decision Support: Build and manage systems and processes to match team skills and interests to the highest impact business needs, in support of PSM priorities.
- Operations Leadership and Culture Building: Operationalize strategic priorities while championing a connected team culture of learning, adaptability, operational excellence, and fun within the team.
- Liaison & Network Integrator: Represent PSM on Product Development workstreams as needed. Take the lead on maintaining a strong Portfolio network with peer groups in gRED, pRED, and GPS.
- Cross-Portfolio Strategy and Special Projects: Partner with senior Pharma leaders and teams to shape portfolio-wide strategy and lead cross-portfolio initiatives and special projects. Structure complex, ambiguous questions, define the work and analysis needed, synthesize evidence and stakeholder perspectives into clear recommendations, and align contributors on plans and milestones to deliver agreed outcomes.
- Portfolio Assessments and Insights: Assess and communicate portfolio dynamics, including risk, value, mix, competitive positioning and performance, to inform portfolio strategy and prioritization. Synthesize quantitative and qualitative analyses, external benchmarking and business planning inputs into clear, executive-ready insights and recommendations.
- Portfolio Decision Quality and Prioritization : Partner with decision-makers to frame portfolio-level choices, assess strategic options and investment trade-offs, and draw on valuation inputs, business cases and risk assessments where relevant. Help shape fit-for-purpose decision pathways and prioritization approaches that support timely, high-quality portfolio decisions.
Who You Are
You bring the following background and experience:
- Bachelor’s degree required; MBA or advanced degree in science, business, or related field preferred.
- Minimum 10 years’ experience in operations, stategy and/or R&D within the biopharma industry.
- Experience in strategy development and linking strategy to tactics.
- Structured problem-solving and strategic thinking skills, with the ability to frame ambiguous questions, synthesize information and develop clear, practical recommendations.
- Strong organizational and project management skills, with the ability to set priorities, manage milestones and dependencies, and deliver special projects.
- Strong understanding of the drug development lifecycle
- Experience in cross-portfolio strategy or portfolio management, including assessing portfolio dynamics, strategic options and prioritization trade-offs.
- Strong analytical acumen, with the ability to interpret portfolio-level risk/value assessments, business cases, metrics and benchmarks and turn them into actionable recommendations.
- Demonstrated experience as a strategic thought partner to senior leaders and teams, with a track record of driving change and innovation.
- Extensive strategic planning, stakeholder management, and operational execution expertise, including leading multiple complex, cross-functional initiatives.
Relocation benefits are not available for this posting
The expected salary range for this position based on the primary location of California is $167,800 - $311,600. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits
Roche is an equal opportunity employer
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .
From 1000 Genentech, Inc.'s careers page (Workday), checked 30 Oct 2026.
How to apply
- Select Apply on gene.com. It opens 1000 Genentech, Inc.'s own application form in a new tab, run on Workday.
- Fill in the form and upload your résumé there. Jobiwork never sees your application.
- 1000 Genentech, Inc. will reply to you directly. No real employer asks you for money to apply.
Posted 29 Oct 2026 · checked 30 Oct 2026 · Report this job
