Structural Biologist III
- Location
- Aliso Viejo
- Work mode
- On-site
- Employment type
- Full-time
About the job
Compensation: $120,000 - $170,000 

 Role Overview The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.
Key Responsibilities
- Provide structural biology support for variant analyses through structure-function relationship interpretation.
- Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
- Partner with statisticians and data scientists to validate algorithms and data collection workflows.
- Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
- Write testable, production-grade code adhering to SDLC standards and code review best practices.
- Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
- Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion
- Support, inform, and educate leadership and stakeholders about project progress and blockers.
Qualifications & Competencies
- Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
- Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
- Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).


 PRIVACY NOTICES
To review Ambry’s Privacy Notice, Click here: https://www.ambrygen.com/legal/privacy-policy To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics To review the UKG privacy notice, click here: California Privacy Notice | UKG Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
From Tempus AI, Inc.'s careers page (Workday), checked 31 Oct 2026.
How to apply
- Select Apply on tempus.wd5.myworkdayjobs.com. It opens Tempus AI, Inc.'s own application form in a new tab, run on Workday.
- Fill in the form and upload your résumé there. Jobiwork never sees your application.
- Tempus AI, Inc. will reply to you directly. No real employer asks you for money to apply.
Posted 11 Sept 2026 · checked 31 Oct 2026 · Report this job
