Biologics Formulation Intern

Kalamazoo - Downtown Portage Street Role Description: We are seeking a talented Biologics Formulations Summer Intern to join our team and contribute to the development of a robust moisture-prediction model for lyophilized drug products. In this role, you will support formulation development and data-driven research efforts aimed at improving the stability, quality, and performance of lyophilized pharmaceuticals.

Biologics Formulation Intern: Advancing Moisture Analytics: Development of a NIR Spectroscopy Method and Chemometric Model for Lyophilized Biopharmaceutical Products Location: Kalamazoo, Michigan

Internship Summary: This 10–12-week internship will focus on developing a rapid, non-destructive Near-Infrared (NIR) spectroscopy method to measure moisture content in lyophilized drug products as a Process Analytical Technology (PAT) tool. The intern will prepare samples across a range of moisture levels, collect paired Karl Fischer (KF) and NIR data, and develop and evaluate a chemometric model, such as partial least squares (PLS) regression. The project aims to enable faster, more efficient moisture analysis and support the future implementation of 100% vial testing and improved lyophilization process development.

Internship Job Duties: · Familiarize and operate freeze-drying/lyophilization equipment and prepare formulations across a defined range of moisture-content targets. · Perform Karl Fischer (KF) titration and acquire Near-Infrared (NIR) spectra using established sample-handling and laboratory procedures. · Develop, optimize, and evaluate chemometric models—such as PLS regression—to correlate NIR spectra with KF moisture measurements. · Process and analyze experimental data, assess model performance, and support method optimization to minimize false-positive and false-negative results. · Conduct laboratory experiments under supervision, document findings, and contribute to technical reports and posters/presentations and analytical-method documentation supporting future PAT implementation. Internship Qualifications:

The following hourly pay rates reflect the anticipated base pay for this position:

If the selected candidate is a student pursuing an Associate-level degree: $16.00 per hour If the selected candidate is a student pursuing an Undergraduate-level degree: $22.00 per hour If the selected candidate is a student pursing a Graduate-level degree: $32.50 per hour If the selected candidate is a student pursuing a Doctorate-level degree: $36.00 per hour

The following hourly pay rates reflect the anticipated base pay for this position if a selected candidate were to be located in California, Connecticut, District of Columbia, Illinois (Chicago area), Massachusetts, New Jersey, New York, Washington (Seattle area):

Student pursuing an Associate-level degree: $17.00 per hour Student pursuing an Undergraduate-level degree: $24.20 per hour Student pursing a Graduate-level degree: $36.40 per hour Student pursuing a Doctorate-level degree: $40.30 per hour

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